Key Publications Rooman Lab
Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in Pancreatic Injury and Cancer Initiation. Baldan J, Camacho-Roda J, Ballester M, Høj K, Kurilla A, Maurer HC, Arcila-Barrera S, Lin X, Pan Z, Castro JL, Guiliani AEM, Rift CV, Hasselby J, Bouwens L, Lefebvre V, David CJ, Parnas O, DelGiorno KE, Erler J, Rooman I, Arnes L. Gastroenterology. 2024 May 9:S0016-5085(24)04911-4. doi: 10.1053/j.gastro.2024.04.031. Epub ahead of print. PMID: 38729450.
Heterotopia of salivary gland tissue in the pancreas. Martens S, Coolens K, Olsen C, Lefesvre P, Rooman I. Diagn Pathol. 2023 Aug 30;18(1):98. doi: 10.1186/s13000-023-01385-x. PMID: 37649044; PMCID: PMC10466737.
High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer. Michiels E, Madhloum H, Van Lint S, Messaoudi N, Kunda R, Martens S, Giron P, Olsen C, Lefesvre P, Dusetti N, El Mohajer L, Tomasini R, Hawinkels LJ, Ahsayni F, Nicolle R, Arsenijevic T, Bouchart C, Van Laethem JL, Rooman I. J Pathol. 2023 Oct 16. doi: 10.1002/path.6212. Epub ahead of print. PMID: 37842959.
Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress. Pan Z, Van den Bossche JL, Rodriguez-Aznar E, Janssen P, Lara O, Ates G, Massie A, De Paep DL, Houbracken I, Mambretti M, Rooman I. Cell Death Dis. 2023 Aug 21;14(8):536. doi: 10.1038/s41419-023-06063-w. PMID: 37604805.
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity. Backx E, Coolens K, Van den Bossche JL, Houbracken I, Espinet E, Rooman I. Cell Mol Gastroenterol Hepatol. 2022;13(4):1243-1253. doi: 10.1016/j.jcmgh.2021.11.010. Epub 2021 Dec 4.PMID: 34875393.
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease. Martens S, Coolens K, Van Bulck M, Arsenijevic T, Casamitjana J, Fernandez Ruiz A, El Kaoutari A, Martinez de Villareal J, Madhloum H, Esni F, Heremans Y, Leuckx G, Heimberg H, Bouwens L, Jacquemin P, De Paep DL, In't Veld P, D'Haene N, Bouchart C, Dusetti N, Van Laethem JL, Waelput W, Lefesvre P, Real FX, Rovira M, Rooman I. Gut. 2021 Jul 30;71(10):2030-42. doi: 10.1136/gutjnl-2020-322874. Online ahead of print.PMID: 34330784.
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions, Backx E, Wauters E, Baldan J, Van Bulck M, Michiels E, Heremans Y, De Paep DL, Kurokawa M, Goyama S, Bouwens L, Jacquemin P, Houbracken I, Rooman I. Cell Death Differ. 2021 Mar 24. Epub ahead of print.
Different shades of pancreatic ductal adenocarcinoma, different paths towards precision therapeutic applications, Martens S, Lefesvre P, Nicolle R, Biankin AV, Puleo F, Van Laethem JL, Rooman I, Ann Oncol. 2019 Sep 1;30(9):1428
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling, Pinho AV, Van Bulck M, Chantrill L, Arshi M, Sklyarova T, Herrmann D, Vennin C, Gallego-Ortega D, Mawson A, Giry-Laterriere M, Magenau A, Leuckx G, Baeyens L, Gill AJ, Phillips P, Timpson P, Biankin AV, Wu J, Rooman I, Nat Commun. 2018 Nov 30;9(1):5083
SOX9 regulates ERBB signalling in pancreatic cancer development, Grimont A, Pinho AV, Cowley MJ, Augereau C, Mawson A, Giry-Laterrière M, Van den Steen G, Waddell N, Pajic M, Sempoux C, Wu J, Grimmond SM, Biankin AV, Lemaigre FP, Rooman I, Jacquemin P, Gut. 2015 Nov;64(11):1790
Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer, Wauters E, Sanchez-Arévalo Lobo VJ, Pinho AV, Mawson A, Herranz D, Wu J, Cowley MJ, Colvin EK, Njicop EN, Sutherland RL, Liu T, Serrano M, Bouwens L, Real FX, Biankin AV, Rooman I, Cancer Res. 2013 Apr 1;73(7):2357
Key Publications Neyns Lab
A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases. Jansen Y, Kruse V, Corthals J, Schats K, van Dam PJ, Seremet T, Heirman C, Brochez L, Kockx M, Thielemans K, Neyns B. Cancer Immunol Immunother. 2020 Jun 26. doi: 10.1007/s00262-020-02618-4. Epub ahead of print.
Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study. Rogiers A, Leys C, De Cremer J, Awada G, Schembri A, Theuns P, De Ridder M, Neyns B. Support Care Cancer. 2020 Jul;28(7):3267
Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy. Seremet T, Jansen Y, Planken S, Njimi H, Delaunoy M, El Housni H, Awada G, Schwarze JK, Keyaerts M, Everaert H, Lienard D, Del Marmol V, Heimann P, Neyns B. J Transl Med. 2019 Sep 5;17(1):303
Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma. Jansen YJL, Rozeman EA, Mason R, Goldinger SM, Geukes Foppen MH, Hoejberg L, Schmidt H, van Thienen JV, Haanen JBAG, Tiainen L, Svane IM, Mäkelä S, Seremet T, Arance A, Dummer R, Bastholt L, Nyakas M, Straume O, Menzies AM, Long GV, Atkinson V, Blank CU, Neyns B. Ann Oncol. 2019 Jul 1;30(7):1154
Randomized phase II trial comparing axitinib with the combination of axitinib and lomustine in patients with recurrent glioblastoma. Duerinck J, Du Four S, Bouttens F, Andre C, Verschaeve V, Van Fraeyenhove F, Chaskis C, D'Haene N, Le Mercier M, Rogiers A, Michotte A, Salmon I, Neyns B. J Neurooncol. 2018 Jan;136(1):115
Combination of dabrafenib plus trametinib for BRAF and MEK inhibitor pretreated patients with advanced BRAFV600-mutant melanoma: an open-label, single arm, dual centre, phase 2 clinical trial. Schreuer M, Jansen Y, Planken S, Chevolet I, Seremet T, Kruse V, Neyns B. Lancet Oncol. 2017 Apr;18(4):464
Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma. Wilgenhof S, Corthals J, Heirman C, van Baren N, Lucas S, Kvistborg P, Thielemans K, Neyns B. J Clin Oncol. 2016 Apr 20;34(12):1330